Superantigen and class II MHC molecules

Superantigen and class II MHC molecules.

Class II Molecules Determines the Intracellular Fate of MHC Class II Molecules and Bound Peptide Hydrogen Bond Integrity Between MHC

A clustered subset of MHC class II molecules.

We have read with great interest the recent Comment by Tobes et al. 1 concerning major histocompatibility complex (MHC) class II 'dimers of dimers' (tetramers, superdimers). The existence of such structures, which could be of essential importance for effective T-cell activation and/or class II-mediated signal transduction in antigen-presenting cells (APCs), has been recently demonstrated 2. Fur...

Signaling through MHC class II molecules blocks CD95-induced apoptosis.

B cells are induced to express CD95 upon interaction with T cells. This interaction renders the B cells sensitive to CD95-mediated apoptosis, but ligation of proviability surface receptors is able to inhibit apoptosis induction. MHC class II is a key molecule required for Ag presentation to Th cells, productive T cell-B cell interaction, and B cell activation. We demonstrate here for the first ...

MHC class II-derived peptides can bind to class II molecules, including self molecules, and prevent antigen presentation

Seven synthetic peptides corresponding to the polymorphic regions of the alpha and beta chains of the I-Ak molecule were examined for their ability to inhibit the presentation of foreign antigens to antigen-specific, I-A-restricted T cell hybridomas. Two of the peptides, representing the sequences found in the first and third polymorphic regions (PMR) of the A alpha k chain (alpha k-1 and alpha...